EDAR Cover in Cell, February 2013

We’re proud to announce a new cover in Cell on February 14th, 2013 on modeling human evolution in mice.

Based on genome-wide screens for adaptive alleles that arose during recent human evolution, Kamberov et al. (pp. 691–702) introduce into mice a variant of the human Ectodysplasin receptor, which originated in central China 30,000 years ago and leads to a single amino acid change. The mice exhibit altered hair thickness and mammary and sweat gland morphology, and these effects mirror differences observed in people according to their Ectodysplasin receptor genotype. A companion paper by Grossman et al. (pp. 703–713) presents a compendium of hundreds of potential adaptive variants as revealed from the analysis of data from the 1000 Genomes Project, providing a roadmap for understanding human biological history and modern day variability.

In order to visually translate this model, we used human footprints that merge into mouse footprints as they run across a map of Asia. Human chromosomes make up the background.




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