Th17 cells play key roles in immune defense and tissue homeostasis but can also become pathogenic and induce autoimmunity. Gaublomme et al. (pp. 1400–1412) use single-cell genomics to reveal the cellular circuit that regulates Th17 cell pathogenicity, and Wang et al. (pp. 1413–1427) show that CD5L acts as a molecular switch that alters lipid metabolism to regulate Th17 function.
Nature Medicine, May 2018 Volume 24, Issue 5 Diffuse midline gliomas (DMGs) with the histone H3 K27M mutation are fatal pediatric tumors. In this issue, Michelle Monje and colleagues report […]
Cover proposal for Cell October 2017 The image in form of a mandala is a representation of diverse tissue and organs that are involved in immune response to vaccination forming […]