Critical regulators of Th17 cell pathogenicity

← Back to the Portfolio

Cell, December 3, 2015
Volume 163, Issue 6

Th17 cells play key roles in immune defense and tissue homeostasis but can also become pathogenic and induce autoimmunity. Gaublomme et al. (pp. 1400–1412) use single-cell genomics to reveal the cellular circuit that regulates Th17 cell pathogenicity, and Wang et al. (pp. 1413–1427) show that CD5L acts as a molecular switch that alters lipid metabolism to regulate Th17 function.

Photoshop and Illustrator.

Critical regulators of Th17 cell pathogenicity

Similar Projects

CAR T cell Therapy for Gliomas

CAR T cell Therapy for Gliomas

Nature Medicine, May 2018 Volume 24, Issue 5 Diffuse midline gliomas (DMGs) with the histone H3 K27M mutation are fatal pediatric tumors. In this issue, Michelle Monje and colleagues report […]

lncRNA Nuclear Enrichment Signals

lncRNA Nuclear Enrichment Signals

EMBO Journal, 15 March 2018 Volume 37, Issue 6 lncRNA Nuclear Enrichment Signals by Chinmay Shukla, Philipp Maas, John Rinn et al: High-throughput identification of RNA nuclear enrichment sequences. RNA […]

Organism-level analysis of vaccination

Organism-level analysis of vaccination

Cover proposal for Cell October 2017 The image in form of a mandala is a representation of diverse tissue and organs that are involved in immune response to vaccination forming […]