CRISPR-Cas9 for Genome Engineering

We recently worked with Patrick Hsu and Feng Zhang on images for their paper “Development and Applications of CRISPR-Cas9 for Genome Engineering“, which was published in Cell on June 5th, 2014. This new technology holds a lot of promised for modifying and editing genomes. Originally this system was discovered in bacteria and the engineered CRISPR-Cas9 system can be programmed to target specific parts of the genetic code. The Cas9 enzyme can be matched with a RNA guide that attaches to DNA targets. Thousands of such guide RNA sequences have already been generated and the CRISPR-Cas9 system can be used to target multiple genes at the same time.

One of the figures we created was an overview of genomic engineering applications. The CRISPR-Cas9 system has the potential to revolutionize genome editing and all current applications. It offers an unmatched degree of precisions and open up new doors for development of new therapeutic tools for genetic diseases.


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